Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC)
نویسندگان
چکیده
منابع مشابه
Pregnancy and the skeletal complications of sickle cell disease.
Introduction Sickle cell anaemia (HbSS) and sickle cell haemoglobin-C disease (HbSC) are the varieties of sickle cell disease usually encountered during pregnancy in Nigeria (Akinla, 1972). The incidence, though low, is certainly increasing. This is because young girls with a chronic haemolytic anaemia who in the past readily succumbed to intercurrent disease and malnutrition are now, with impr...
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Little data exist for the mechanical properties of individual irreversible or reversible sickle cells (ISC and RSC, respectively), nor is the process of ISC formation well understood. For oxygenated ISC and density-fractionated RSC, we have used micropipette techniques to measure cell surface area (SA) and volume (V), membrane shear elastic modulus (mu), time constant for viscoelastic shape rec...
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BACKGROUND Albuminuria is a marker of glomerular damage in Sickle Cell Disease (SCD). In this study, we sought to determine the possible predictors of albuminuria in the two more prevalent genotypes of SCD among the Jamaica Sickle Cell Cohort Study participants. METHODS An age-matched cohort of 122 patients with HbSS or HbSC genotypes had measurements of their morning urine albumin concentrat...
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The present study, wants to highlight and review the most prevalent disease amongst travelers. In the current review, an updated review regarding epidemiology, involved pathogens, and a brief review of current evidence-based guidelines for prevention and treatment of this disease are provided. A distinguishing feature of the current review is the discussion of the impacts of irritable bowel syn...
متن کاملGenetic modulation of HbF in Brazilians with HbSC disease and sickle cell anemia.
may even be asymptomatic and not diagnosed until much later in life [3,4]. In contrast, heterozygous patients with N370S=other present earlier and show predominantly visceral disease and more severe skeletal involvement [4]. Our patient has heterozygous mutation N370S=G377S. Unlike N370S, the G377S mutation is rare and usually seen in patients of Portuguese and Spanish descent [1] and is also s...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2020
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0228399